background: irritable bowel syndrome (ibs) with chronic abdominal pain and changes in bowel habits in the absence of any organic cause is identi_ed as the most common known gastrointestinal disorder. ibs affects both sexes and can occur at any age. diagnosis of this disease in younger patients and women is more likely. in the pathophysiology of ibs, hereditary, environmental, visceral, psycholo...

gamma aminobutyrate (gaba) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. mechanisms by which gaba may facilitate these responses to stress are metabolic and/or mechanical disruptions. environmental stresses increase gaba accumulation through cytosolic acidification, induce an acidic ph-dependent activation of glutamate...

Gamma aminobutyrate (GABA) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. Mechanisms by which GABA may facilitate these responses to stress are metabolic and/or mechanical disruptions. Environmental stresses increase GABA accumulation through cytosolic acidification, induce an acidic pH-dependent activation of glutamate...

BACKGROUND Limited studies of hypothalamic-pituitary-adrenal axis regulation in posttraumatic stress disorder have been performed in premenopausal women. We therefore undertook a study of hypothalamic-pituitary-adrenal axis regulation in this population. METHODS Outpatient posttraumatic stress disorder subjects were compared with healthy, age- and weight-matched nontraumatized subjects. Subje...

introduction: to measure radiation exposures rate in low-risk patients having stress-only and stress-rest myocardial perfusion imaging. methods: this was a prospective study conducted from january 2012 till november 2012 upon patients with low pre-test probability for coronary artery disease (cad). a stress mpi (stress-only if mpi is normal and no resting study) followed by a resting mpi study...

There is a growing body of experimental and clinical evidence to indicate that stress influences gastrointestinal motility. The most common pattern of gastrointestinal motor alterations induced by a variety of different stress factors is that of delayed gastric emptying and accelerated colonic transit. Central administration of corticotrophin releasing factor mimics both of these effects. This ...

There is a growing body of experimental and clinical evidence to indicate that stress influences gastrointestinal motility. The most common pattern of gastrointestinal motor alterations induced by a variety of different stress factors is that of delayed gastric emptying and accelerated colonic transit. Central administration of corticotrophin releasing factor mimics both of these effects. This ...

A hierarchical hormonal cascade along the hypothalamic-pituitary-adrenal axis orchestrates bodily responses to stress. Although corticotropin-releasing hormone (CRH), produced by parvocellular neurons of the hypothalamic paraventricular nucleus (PVN) and released into the portal circulation at the median eminence, is known to prime downstream hormone release, the molecular mechanism regulating ...